The Best PDRN Skincare in Singapore

PDRN skincare is the latest trend coming out of Korean beauty right now: it promises to rejuvenate your skin, plump and hydrate, and speed up skin cell turnover for faster repair and anti-aging effects. Like other genius K-beauty ingredients snail mucin and tremella mushroom, you might be wondering if PDRN has a similarly unexpected source. It has to do with fish.

An Introduction to PDRN Skincare

PDRN stands for “polydeoxyribonucleotides”, and is derived from salmon DNA fragments (ethically!), most commonly used in medspas in Korea. There, PDRN is injected into the skin or scalp for anti-aging, hair growth-stimulating purposes. The DNA sequences in PDRN greatly resemble human DNA sequences, making it ideal to kickstart the skin turnover process wherever it’s needed.

It’s only recently that PDRN has caught on as a topical treatment, appearing in serums, creams, and overnight masks. If you’re vegan or just don’t like seafood all that much, animal-free PDRN formulas are also available: these are lab-created synthetic PDRN products with all of the freshness and none of the fish. Both vegan and animal-based formulas have the similar effect of giving your skin a lit-from-within glow, plus plenty of long-term benefits.

Ready to dive in? We’ve found you the best PDRN products, from multi-active skin boosters to simple PDRN creams.

If you're new to all skincare, The Ordinary shows you how to build a routine from scratch.

Plant-based PDRN Formulas: Synthetic PDRN Skincare

VT PDRN Essence 100 – Innovative Vegan PDRN Skincare For Glowing Skin

Korean brand VT tends to pioneer some of the industry’s most ingenious formulas, like the Reedle Shot 100 Serum: the PDRN Essence 100 sounds much less terrifying and much more agreeable. It joins VT’s full line of PDRN-infused skincare products, which includes a PDRN Capsule Cream, for reducing fine lines and encouraging a glow.

The PDRN Essence 100 uses Phyto PDRN®, suitable for vegans: it’s derived from Korean ginseng, which combines the deep restorative properties of the PDRN compound and the benefits of ginseng. It additionally contains CERASOME Complex Plus, a blend of ceramides which creates radiant skin. Unscented and non-irritating, this essence is suitable for sensitive skin, and is particularly effective for treating skin with a damaged moisture barrier.

If you’d like to try PDRN in a form closer to its original medspa use, VT also offers the PDRN Reedle Shot Hair Ampoule, which combines the signature Cica Reedle technology with PDRN for a revitalised scalp. The “reedles” in question are tiny, noninvasive “micro-needles” which dissolve upon contact and allow active ingredients to absorb more thoroughly.

Shop the VT PDRN Essence 100 at Watsons Singapore.

SOME BY MI PDRN Spirulina Soothing Repair Serum – Skin-Soothing PDRN Skincare Formula From Spirulina

Another plant-based PDRN formula, SOME BY MI’s PDRN Spirulina Soothing Repair Serum, derives its synthetic PDRN from spirulina: this nutrient-rich algae is already used in skin supplements and an Erewhon gut-health smoothie. SOME BY MI gives topical spirulina a go, citing its stability as compared to salmon-derived PDRN and skin-protecting qualities.

The PDRN Spirulina Soothing Repair Serum contains marine amino acids, which quickly cool the skin surface to soothe inflammation and redness. With two types of peptides, it reduces texture and reinforces the skin barrier, and its gel-like texture means easy absorption. This formula is proven hypoallergenic, non-comedogenic, and vegan.

This serum has an additional benefit besides skin toning: it’s also said to reduce acne, minimise pores and control sebum production. This occurs because the skin’s inflammatory response is a common cause of acne, and cooling the skin can reduce oil production in humid weather. It’s a signature skincare formulation style of Korean beauty: less exfoliating acids, more hydration.

Shop SOME BY MI’s PDRN Skin Booster on Shopee Singapore.

Dear, Klairs Freshly Juiced Vitamin Essence Toner – With Vegan PDRN For Dark Spot Care

Struggling with hyperpigmentation or scarring? Dear, Klairs’ Freshly Juiced Vitamin Essence Toner might do the trick. Like many other PDRN-enriched skincare products on this list, this toner is enhanced with Dear, Klairs’ own vegan PDRN compound: this time, it’s derived from rice.

This toner is packed with skincare actives: rice PDRN, with a lower molecular weight than salmon PDRN, sinks into the skin and provides cushiony moisture. Lipsomal gluthathione, a compound with inhibits dark spot formation with an antioxidant effect, protects against dullness and discolouration, and a special capsule technology allows for deeper delivery of vitamins and hydratants. Of course, vitamin C balances skin tone and boosts radiance.

Remarkably, the Freshly Juiced Vitamin Essence Toner remains suitable for sensitive skin despite an incredible number of active ingredients.  Fragrance-free and lightweight, this powerhouse toner promises to reduce dark spots in as little as three days.

Shop Dear, Klairs’ Freshly Juiced Vitamin Essence Toner on Shopee Singapore.

Abib PDRN Collagen Overnight Mask – Luxurious PDRN Evening Skincare

Abib’s legendary overnight mask formulas are joined by the PDRN Collagen Overnight Mask, a soft pink jelly-like sleeping mask with all the benefits of vegan PDRN. Designed as the last step of your skincare routine, this mask seals in all your skincare with panthenol and promotes skin elasticity.

Infused with low molecular collagen and niacinamide, the Collagen Overnight Mask is a fix-it-all formula that addresses dark spots, aging skin, irritation and damaged skin barriers. Since Abib’s formula of plant-based PDRN is nothing but soothing, the mask can be used every night without fear of clogging pores. It is an overnight mask product, though, so make sure to clean your pillowcases frequently!

Abib also offers a PDRN Collagen Lip Mask Glazed Jelly, an overnight lip balm with the same active ingredient. It has a runnier gel texture, smells faintly like caramel, and is a dream to apply with its little spatula and dome-shaped bottle.

Shop the Abib PDRN Collagen Overnight Mask online.

Animal-based PDRN Formulas: Derived From Salmon DNA

Genabelle PDRN Rejuvenating Cream – Simple But Advanced PDRN Skincare Formula

Genabelle’s PDRN Rejuvenating Cream is about as simple as it gets: salmon-based PDRN with several soothing, hydrating ingredients. The brand produces a whole PDRN line, including a Vita Toning Ampoule and Rejuvenating Eye Mask, but the Rejuvenating Cream remains the easiest way to add PDRN to your daily routine.

The Rejuvenating Cream is a lightweight cream moisturiser that can be used both day and night, in any climate. Its formula pairs the active ingredient PDRN with centella asiatica, Ceramide NP, and a patent blend of skin soothers: the HTD-GENACOMPLEX™ contains hyaluronic acid and tripeptide-1. Together, they work to hydrate all skin types, including dry, oily and combination skin, and protect it from irritation.

If you’d like to double or triple your PDRN dose, a full kit of PDRN skincare from Genabelle is available for purchase: a Rejuvenating Toner, ampoule, cream and PDRN mask make a whole skincare routine. The PDRN Rejuvenating Full Set can be purchased here.

Shop Genabelle’s PDRN Rejuvenating Cream online.

Anua PDRN Hyaluronic Acid Capsule 100 Serum – Lightweight, Effective PDRN Skincare

Fans of Anua’s viral Heartleaf Clear Pads who want a little more soothing than exfoliation can look forward to the PDRN Hyaluronic Acid Capsule 100 Serum: this lightweight gel serum contains hyaluronic acid and hydrolysed collagen to keep your skin looking plumped and smooth. Infinitely layerable and low-irritation tested, it sinks into your skin even on the warmest days.

Anua’s PDRN formulation is animal-based, derived from the standard salmon DNA. For better absorption with topical use, it’s paired with an 11-layered hyaluronic acid complex and a low-molecular, far-reaching hydrolysed collagen. The brand recommends that the serum be used throughout the day: a light layer in the morning, 2-3 layers in the evening as a “sleeping mask”, and even 1-2 drops mixed into makeup for a radiant finish. It contains no artificial fragrance, though users with sensitive skin may want to note low levels of niacinamide.

Shop Anua’s PDRN Hyaluronic Acid Capsule 100 Serum on Cocomo.

Medicube PDRN Pink Peptide – PDRN Skincare For Fading Dark Spots

With its appropriately cheery bright salmon colour and lightweight texture, Medicube’s PDRN Pink Peptide Serum has been making waves online for its simple ingredient list and ease of use.  This serum has dual functionality in improving fine lines and removing discolouration, helping you maintain a smooth and glowing complexion.

Besides salmon-DNA PDRN, the serum also includes five kinds of peptides: they boost collagen production, firm the skin, and strengthen the skin barrier. Adenosine, an essential biologically identical compound, smooths fine lines, speeds up skin repair, and supports healthy skin structure. The Pink Peptide serum also contains the valuable herb tulsi, known for its anti-inflammatory and protective properties.

Medicube suggests pairing this product with the Zero Exosome Shot serum: a microneedle booster product that works with the Pink Peptide Serum to produce an effect similar to PDRN injections in Korean medspas.

Shop the Medicube PDRN Pink Peptide serum online.

Heveblue Salmon Caring Centella Cream – Calming PDRN Skincare With Madecassoside

The Salmon Caring Centella Cream from Heveblue is packed with Korean beauty’s favourite skincare ingredients: centella asiatica, madecassoside, and PDRN derived from salmon. This is a cream moisturiser formula: it’s dense, heavily moisturising, and suitable for extremely dry and damaged skin. It’s hypoallergenic, good for all skin types (including oily!) and works as both a day cream and night cream: its effectiveness on scaly skin patches might even make it good to treat facial eczema.

There’s more in this cream: rice bran water and milk protein are responsible for its rich texture, which help to deliver nutrients to and plump up the skin. A natural avocado peptide, the patented EFFIPULP, is used to protect skin from external irritants. On top of all this, salmon roe extract is used to give vitality to tired-looking skin and boost radiance. Heveblue suggests applying a thick layer of the cream before bed, like a sleeping mask, to deliver its full benefits.

Shop Heveblue’s Salmon Caring Centella Cream online on Pupsik.

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